Mount Sinai Receives Prestigious $ 4 Million Grant To Launch Skin Biology and Disease Resource Center

The Icahn School of Medicine at Mount Sinai is in the process of establishing a skin biology and disease resource center, funded by a five-year, $ 4 million P30 grant from the National Institutes of Health and the National Institute of Arthritis, Musculoskeletal and Skin Diseases.

New York, NY (October 20, 2021) – Icahn Mount Sinai School of Medicine is establishing Skin Biology and Disease Resource Center (SBDRC), funded by $ 4 million P30 grant over five years of the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The Mount Sinai SBDRC will serve as a hub for skin biology and skin disease research throughout the Mount Sinai Health System in New York City and across the Tri-State region, one of the six SBDRCs nationwide supported by a NIAMS grant.

The Mount Sinai SBDRC will be led by Elena Ezhkova, PhD, Professor of Cellular, Developmental and Regenerative Biology and Dermatology, at the Black Family Stem Cell Institute at Icahn Mount Sinai. She is an internationally recognized leader in the study of skin epigenetics. Dr Ezhkova’s most recent study, published in Development cell, found that exposure to ultraviolet light produces epigenetic changes in the epidermis to induce skin pigmentation.

“This new center will continue our efforts at Mount Sinai to accelerate research on the biology and diseases of the skin, and promote the translation of this understanding for the benefit of our patients throughout the healthcare system,” said Dr. Ezhkova. “We will also ensure a vibrant future for skin biology and disease research by helping the early career and development of external researchers and physician-researchers through training and financial support, as well. than by enhancing the diversity of our research community through the targeted recruitment and mentoring of young scientists from all walks of life.

Sarah Millar, PhD, Director of the Black Family Stem Cell Institute and Lillian and Henry M. Stratton Professor of Gene and Cell Medicine, and Emma Guttman, MD, PhD, Waldman Professor of Dermatology and Chair of the Kimberly and Eric J. Waldman System Department of Dermatology, at Icahn Mount Sinai, will serve as the Center’s associate co-directors.

The Center will use technical innovations, high-end infrastructure and the computing power available at Mount Sinai to advance and support skin research, and integrate experts in gene editing, genomics and bioinformatics in the laboratories of skin research to remove barriers to interdisciplinary communication. The SBDRC program will also offer in-person and virtual events, such as ongoing research seminars and conferences, to facilitate collaboration in skin biology and disease. The Center will promote research and innovation through three core resources: modeling skin diseases; Skin genomics, transcriptomics and epigenetics; and data analysis and integration.

Pursuing Mount Sinai’s commitments to diversity, inclusion and equity, SBDRC will award pilot grants and scholarships to reduce financial barriers and expand access to advanced technologies for innovative projects, and establish the Mount Sinai Skin Scholars program to create a portfolio of under-represented high schools. students entering skin research.

“Skin biology research is extremely strong at Mount Sinai and we have recently recruited other very talented professors in this field,” said Dr. Millar, an expert in skin development, stem cells and regeneration. “The SBDRC will provide a very important platform for us to synergize our research and increase our interactions with new SBDRC members in other institutions. “

Dr Guttman, a world-renowned expert in the molecular and cellular mechanisms of inflammatory skin diseases, said the grant will be a vital contribution to the future of dermatology research and help foster further discoveries in the diseases. skin.

“The Skin Biology and Disease Resource Center will be very important in fostering further research in dermatology at Mount Sinai, both on model systems and at the human interface, and will assist our investigators and external investigators. in their skin research, ”she said. noted.

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