Evaluate business – DC Writers Way http://dcwritersway.org/ Mon, 19 Sep 2022 22:00:00 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://dcwritersway.org/wp-content/uploads/2021/05/cropped-icon-32x32.png Evaluate business – DC Writers Way http://dcwritersway.org/ 32 32 Perpetua Resources receives Department of Defense funding to study antimony from the Stibnite Gold project https://dcwritersway.org/perpetua-resources-receives-department-of-defense-funding-to-study-antimony-from-the-stibnite-gold-project/ Mon, 19 Sep 2022 22:00:00 +0000 https://dcwritersway.org/perpetua-resources-receives-department-of-defense-funding-to-study-antimony-from-the-stibnite-gold-project/

Global conflicts and fractured supply chains have strained the United States’ ammunition supply.

The grants will be used to evaluate whether antimony samples from the Stibnite Gold Project can meet military specifications for the United States ammunition supply chain.

The Stibnite Gold Project is expected to be the only exploited source of the critical mineral antimony in United States.

BOISE, ID, September 19, 2022 /PRNewswire/ – Perpetua Resources Corp. (NASDAQ: PPTA) (TSX: PPTA) (“Perpetua Resources” or “Perpetua” or the “Company”) today announced that the Company has received two funding grants from the U.S. Department of Defense (“DOD”) Defense Logistics Agency (“DLA”) to study domestic production of weapons-grade antimony trisulfide, a critical component of munitions and dozens of other defense materials. Perpetua will receive $200,000 in total to assess whether antimony from the Stibnite Gold Project (“Project”) can meet military specifications (“Mil-Spec”) to help secure America’s commercial and defense ammunition supply chain while evaluating alternative methods to purify antimony trisulfide.

“Antimony from the Stibnite Gold Project site served our national defense needs during World War II (“WWII”) and Perpetua is confident that we can once again be part of the solution,” said Laurel Sayer, President and CEO of Perpetua Resources. “We are grateful for this opportunity to work with the Department of Defense to demonstrate that our project can develop reliable, domestically sourced antimony trisulfide for defense and commercial munitions. It would be a great honor to support the independence of our country’s defense supply chains and the brave men and women who serve our country.”

Perpetua has submitted two proposals under DLA’s “Production of Energetic Materials and Associated Precursors” Small Business Innovation Research (“SBIR”) tender. As described in the grant objective, the program is focused on reducing “foreign dependence and single points of failure for domestic manufacturing of energy materials” through the development of a domestic source. After a competitive review process, Perpetua was awarded SBIR Phase 1 funding to $100,000 for both programs. Each study is expected to be completed within the next six to twelve months.

The first program will test existing samples of antimony trisulfide ore from the project for development into antimony trisulfide according to Mil-Spec. The second program will investigate alternative processing possibilities to develop Mil-Spec antimony trisulfide from high purity metallic antimony. After the proposed programs are completed, Phase 2 funding could be made available for more advanced pilot-scale testing over the next year. Together, the Phase 1 and 2 programs could confirm the Project’s ability to provide the domestic source of antimony needed to meet defense supply demand and support commercial markets.

Antimony trisulfide is produced from high purity antimony ore raw materials and is used in small and medium caliber munitions, mortars, artillery, mines, flares, grenades, shoulder-launched ammunition and missiles. Currently, China, Russiaand Tajikistan control about 90% of the world’s supply of antimony and United States does not have a nationally mined source of the critical mineral. The Stibnite Gold Project proposed by Perpetua hosts one of the largest deposits of antimony in the world, regardless of China, Russia and their interests.

The recent global conflict and supply chain instability has impacted access to the high purity antimony ore feedstock needed to produce Mil-Spec antimony trisulfide. In June 2022the House Armed Services Committee reported that Chinese and Russian geopolitical dynamics could “accelerate supply chain disruptions, particularly for antimony” and asked the National Defense stockpile manager to brief the committee on five-year antimony inventory and supply chain outlook. .

The centrally located Stibnite gold project Idaho, is progressing into its sixth year of review under the National Environmental Policy Act. The project is designed to restore environmental conditions in the historic Stibnite mining district while responsibly developing one of the world’s richest open pit gold resources. United States and become the only national source of the critical mineral antimony. Mining activity began in the district in the early 20th century for gold and silver. During World War II and the Korean War, the U.S. government commissioned production of antimony and tungsten at Stibnite under the authority of the Strategic Metals Act of 1939. The site produced over 90% of the antimony used by the United States during World War II and played an important role in establishing Mil-Specification for antimony trisulfide.

About Perpetua Resources and the Stibnite Gold Project
Perpetuates Resources Corp., through its wholly owned subsidiaries, is focused on the exploration, site reclamation and redevelopment of gold-antimony-silver deposits in the Stibnite-Yellow Pine district of central Idaho which are encompassed by the Stibnite gold project. The project is one of the richest open pit gold deposits in United States and is designed to apply a modern and responsible mining approach to restore an abandoned mine site and produce both gold and the only source of antimony mined in United States. Advance further Perpetuates Resources’ ESG and sustainable mining objectives, the project will be powered by the lowest carbon emitting grid in the country and a portion of the antimony produced by the project will be supplied to Ambri, a US-based company that markets a low-cost liquid metal battery essential to the low-carbon energy transition. In addition to the company’s commitments to transparency, accountability, environmental stewardship, safety and community engagement, Perpetuates Formal Adopted Resources ESG commitments that we find here.

Forward-looking information
Statements contained in this press release that are not historical facts are “forward-looking information” or “forward-looking statements” (collectively, “forward-looking information”) within the meaning of applicable Canadian securities laws and the Private United States Securities Litigation. Reform Act of 1995. Forward-looking information includes, but is not limited to, disclosure of possible events, next steps and plans of action, including environmental cleanup actions by us and our sub- contractors; our ability to comply with and obtain permits related to the Stibnite Gold Project; action to be taken by the USFS, the Idaho State and other governmental and regulatory agencies and the expected results of their review; plans for the issuance of an SDEIS and any designation thereunder; the planned timetable for the publication of the SDEIS; forecasts regarding the improvement of environmental conditions at the site; reduction of project footprint and anticipated benefits and other effects; our ability and that of Ambri, Inc. to perform the supply agreement, which agreement is subject to certain conditions, including the identification of one or more refiners to process our antimony concentrate into antimony metal, and mutual agreement on certain important terms, including volume and pricing: our ability to develop antimony under Mil-Spec; and the timing and expected results of DLA-funded studies will be successful and as expected. “, “expect to”, “plan”, “likely”, “believe”, “intend”, “expect”, “project”, “estimate”, “potential”, “could”, “may” , “will”, “would”, or “should”. In preparing the forward-looking information contained in this press release, Perpetua Resources applied several important assumptions, including, but not limited to, assumptions that current exploration, development, environmental and other objectives regarding the Stibnite Gold Project can be achieved and that its other business operations will proceed as planned; that we will be able to develop antimony to Mil-Spec in these tests and in the future; that we and Ambri will be able to agree to the terms of the Ambri Agreement; that general business and economic conditions will not change materially adversely and permitting and operating costs will not increase materially; and that the review process under NEPA (including the review process involving the USFS, any review process by the Idaho State and other regulatory agencies and bodies and consultation with Idaho tribes) as well as the public review process and the SDEIS will proceed in a timely manner and as planned; and that all required information will be available in a timely manner. Forward-looking information is based on certain important assumptions and involves known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of Perpetua Resources to be materially different from future results, performance or achievements. expressed or implied by the forward-looking information. These risks and other factors include factors discussed in Perpetua Resources’ public filings with the United States Securities and Exchange Commission (the “SEC”) and its Canadian disclosure filings. Although Perpetua Resources has attempted to identify important factors that could affect Perpetua Resources and cause actual actions, events or results to differ materially from those described in the forward-looking information, there may be other factors that cause actions, events or results not to be as intended, estimated or intended. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information. For more information on these risks and on other risks and uncertainties that could affect the Company’s activities, see the sections “Risk factors” and “Management’s discussion and analysis of the financial situation and results of ‘use’ of documents filed by the Company with the SEC, which are available at www.sec.gov and with the Canadian securities regulators, which are available at www.sedar.com. Except as required by law, Perpetua Resources undertakes no obligation to publicly release any revisions to the forward-looking information contained in this press release to reflect events or circumstances after the date hereof or to reflect the occurrence of unforeseen events. .

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SOURCEPerpetua Resources Corp.

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Brazil sends record delegation to IBIE https://dcwritersway.org/brazil-sends-record-delegation-to-ibie/ Sun, 18 Sep 2022 04:00:00 +0000 https://dcwritersway.org/brazil-sends-record-delegation-to-ibie/

For the first time in three years, the global baking community is coming together again at the International Baking Industry Exposition (IBIE), taking place September 17-21 in Las Vegas. Among the largest international delegations is Brazil, which has more than 70,000 bakeries serving 200 million people with a wide variety of pastries, breads and other baked goods.

Baking & Snacking magazine contacted Rui Gonçalves, president of Sampapão, an association that brings together 6,000 bakeries in São Paulo. Sampapão is the acronym for São Paulo bakery and confectionery entities.

The organization is responsible for managing FIPAN, held in July and is the largest bakery and confectionery fair in Latin America and one of the main events for catering operators in the country.

Over the years, said Mr. Gonçalves, FIPAN and the Brazilian baking community have collaborated in many ways with IBIE and the US baking industry. Mr. Gonçalves shared his perspective on the Brazilian bakery market and a global perspective on the bakery industry as a whole.

How would you describe the state of the bakery industry in Brazil, especially since the pandemic hit?

Bakeries in Brazil have become a center of food production and convenience. The product range, previously focused on bread, milk and coffee, has become much more diverse and complete for the customer, with options for breakfast, pizzas, soups, products for convenience stores, among others. We focus on the 24 hour routine of our customers, being present at all times of the day, every day of the week. The bakery industry in Brazil has already recouped the losses it suffered during the pandemic and already the sales volume is slightly higher than in 2019. Another important point is that sales per delivery have increased, accelerating a trend that already existed before the pandemic.

How do you rate the strength of the Brazilian economy and its impact on the baking industry?

The bakery industry accounts for around 20 billion dollars (US dollars) per year, indicating a significant importance in the gross domestic product (GDP) of the country. Even with the pandemic, the strength of the bakery industry, as it is an essential activity and of national public interest according to law, remained open and continued to have daily sales, even if they are much lower than the pre-COVID phase. Compared to the economies of European countries and the United States, we have lower inflation, a recovery in the level of employment and GDP is expected to grow by 2.5% this year. Brazil continues to be the country of opportunities, with more than 200 million consumers and a constant evolution of various sectors, such as bakery, which increasingly seeks efficiency and international technology.

What are the current consumer and market trends driving sales in Brazil, and how do they differ from other countries in North and South America?

Food delivery has certainly been the biggest change post-pandemic. Bakeries have become experts in this type of service. Now, in addition to having know-how in customer service and craft production, we can quickly acquire experience in delivery, which is here to stay and which is evolving every day. Consumers have missed being at the bakery, so bakeries are taking advantage of this to improve services and retain customers even more.

How do bakeries deal with supply chain issues, especially around ingredients and packaging?

With the pandemic, many other packaging vendors have emerged in the industry. The number of businesses has almost tripled, largely due to delivery. In this way, the options for the market have increased a lot. Despite the lack of inputs, we have more products on the market and more options for suppliers. A negative factor was higher prices, especially of wheat, which we were unable to fully pass on to consumers. We have also adapted to other types of raw materials and ingredients to continue production, which has resulted in prospecting new suppliers every week and reviewing all contracts with them, leaving establishments freer and that can serve, even with less production, eager customers. to buy everyday products. The rule is to always have options for customers.

What is the labor situation in Brazil and how does it compare to the challenges faced by bakeries in other parts of the world?

Our sector employs 2.5 million Brazilians, but skilled labor issues persist, especially after the pandemic. The offer exists, but the demand must be more nuanced, which is why we have several educational projects at the FIPAN show and in our school, the IDPC, which offers a range of professional training for the entire sector. If we do not encourage vocational training, the baking industry will not evolve.

Why has FIPAN been so successful this year?

Lots of work and lots of planning. We have certainly conquered new markets and new audiences, bringing to our show what the bakery sector needs. FIPAN is the education, networking and business platform for the bakery sector in Brazil and also in the partner countries. Baking professionals from more than 30 countries visited FIPAN, which registered a record number of 360 exhibitors, 450 brands and more than 42,000 square meters of exhibition space. Our congress also included topics on 5G technology, delivery with drones, energy efficiency and other topics to prepare the baking industry for the future.

How does FIPAN work with IBIE to exchange knowledge between Brazil and North American baking industries?

We are at IBIE with a record delegation of Brazilian businessmen. There are around 50 owners looking for innovation and business at the show. We want a technology-oriented exchange and more efficient production between IBIE and FIPAN companies. So much so that we will participate in business roundtables and technical visits during the IBIE – just as they also had the opportunity to have a positive agenda with us during the last FIPAN. The bakery world must unite to be stronger.

What would be the demand for foreign equipment, products and technologies in Brazil?

Brazilians are looking for machinery and inputs that bring more efficiency to their production. We have found technologies that are not yet in the Brazilian sector, and that is why we have organized these delegations to bring to Brazil suppliers capable of meeting this suppressed demand. After all, there are over 200 million Brazilians and over 70,000 bakeries to serve them, so the opportunity for growth is huge.

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The Biden administration just rolled out recommendations to regulate crypto that signal the potential for a digital dollar and tougher penalties to crack down on crime https://dcwritersway.org/the-biden-administration-just-rolled-out-recommendations-to-regulate-crypto-that-signal-the-potential-for-a-digital-dollar-and-tougher-penalties-to-crack-down-on-crime/ Fri, 16 Sep 2022 14:21:43 +0000 https://dcwritersway.org/the-biden-administration-just-rolled-out-recommendations-to-regulate-crypto-that-signal-the-potential-for-a-digital-dollar-and-tougher-penalties-to-crack-down-on-crime/

The White House on Friday released a comprehensive framework that offers recommendations for regulating cryptocurrencies after a six-month review of digital assets.

The report follows a March executive order from President Biden that directed federal agencies to continue crypto research.

New Biden administration framework calls for more private innovation in the digital asset space while asking both the Securities and Exchange Commission and the Commodity Future Trading Commission to crack down harder on theft and crime across the sector.

It also comes after May’s crypto crash wiped out $600 billion from crypto investments, as the sector is still under pressure from Federal Reserve interest rate hikes and persistent inflation.

The report also touched on the Federal Reserve’s plan for a central bank digital currency, which the White House said “has the potential to deliver significant benefits.” The report warns that a CBDC still has immense consequences, including “CBDC runs in times of stress.”

Meanwhile, the White House has signaled that Congress may need to get involved in tougher sanctions to crack down on illicit activity.

“The President will consider whether to ask Congress to amend the Bank Secrecy Act, anti-whistleblower laws, and laws against unlicensed money transmission to explicitly apply to digital asset service providers. , including digital asset exchanges and non-fungible token (NFT) platforms,” a White House briefing said.

The administration is also considering asking Congress to toughen penalties for transmitting money without a license and changing laws to facilitate the Justice Department’s ability to prosecute crimes related to digital assets.

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Hovde Group expands its custody team with the addition of an investment banking group led by veterans Craig Mancinotti and Rick Maroney https://dcwritersway.org/hovde-group-expands-its-custody-team-with-the-addition-of-an-investment-banking-group-led-by-veterans-craig-mancinotti-and-rick-maroney/ Mon, 12 Sep 2022 14:05:00 +0000 https://dcwritersway.org/hovde-group-expands-its-custody-team-with-the-addition-of-an-investment-banking-group-led-by-veterans-craig-mancinotti-and-rick-maroney/

CHICAGO–(BUSINESS WIRE)–Hovde Group, LLC (“Hovde”), a leading full-service investment bank and broker-dealer that provides investment banking, capital markets, equity research and sales and trading firm focused on the financial services industry, today announced that it is adding an investment banking team led by Craig Mancinotti and Rick Maroney, who will serve as senior managing directors of Hovde’s depository practice . The investment banking team also includes Mike Moran, managing director, and four other investment banking professionals.

Hovde will open a new office in Toledo, OH, which Mancinotti and Maroney will manage. They will be responsible for providing investment banking and select advisory services, including M&A and capital markets advisory solutions to depository institutions throughout the Midwest and other markets across the country. . Mancinotti and Maroney each have nearly 40 years of community banking experience, most recently as managing directors of ProBank Austin. They have been involved in over 250 successful M&A transactions representing both buyers and sellers.

Mancinotti and Maroney are frequent speakers at nationwide conferences for state and national organizations, including the annual Bank Manager’s “Get or Be Owned” lecture. They have also been cited as industry experts in industry newspapers and periodicals across the country, including S&P Global Market Intelligence, The Wall Street Journal and CNBC.

“We have known Craig and Rick for many years, have faced them on many deals and followed their success across the country,” commented Kirk Hovde, Managing Director and Head of Investment Banking. “As we continue to evaluate growth opportunities for our business, we view the addition of Craig and Rick, and their team, as a natural fit to strengthen our presence in the Midwest, given their extensive experience, entrepreneurial spirit and, above all, their reputation for providing excellent service to their customers.”

Mancinotti & Maroney added: “In recent years we have seen Hovde Group continue to grow with the addition of Capital Markets, Research and Sales & Trading, as well as being consistently ranked as one of the top M&A advisers most active with community banks. The combination of Hovde’s platform and culture is unmatched in our opinion and made the decision much easier. Joining Hovde offers an exciting opportunity to leverage our client relationships with an expanded range of services and execution skills.

The move will take effect on October 1, 2022.

]]> Five-year data from Xevinapant shows survival rate nearly doubles in patients with unresected SCCHN when added to standard of care https://dcwritersway.org/five-year-data-from-xevinapant-shows-survival-rate-nearly-doubles-in-patients-with-unresected-scchn-when-added-to-standard-of-care/ Wed, 07 Sep 2022 22:05:00 +0000 https://dcwritersway.org/five-year-data-from-xevinapant-shows-survival-rate-nearly-doubles-in-patients-with-unresected-scchn-when-added-to-standard-of-care/

ROCKLAND, Mass.–(BUSINESS WIRE)–EMD Serono, the healthcare business of Merck KGaA, Darmstadt, Germany, USA and Canada, today announced that the IAP (inhibitor of apoptosis protein) inhibitor xevinapant (formerly known as Debio 1143) plus chemoradiotherapy (CRT) has significantly improved long-term efficacy outcomes in patients with unresected locally advanced squamous cell carcinoma of the head and neck (LA SCCHN ) compared to placebo plus CRT. Adding xevinapant more than halved the five-year risk of death compared to placebo. These late-breaking data from the 96-patient phase II trial will be presented during the Head and Neck Cancer Oral Mini-Session on September 10, 2022 at 10:55 a.m. CEST (Abstract #LBA33) at the European Society of Medical Oncology Congress 2022.

“There is a clear need for improved treatment options for patients with unresected locally advanced head and neck cancer. Chemoradiotherapy has served as the standard of care in this setting for decades, yet half of patients treated with CRT see their cancer come back, either locally or as metastatic disease,” said Professor Jean Bourhis, MD. , Ph.D., Head of the Radiation Oncology Department at Lausanne University Hospitals and principal investigator of the study. “The five-year results of this randomized phase II study are the first to show improved efficacy outcomes compared to standard of care for these patients and suggest the potential of xevinapant to increase the proportion of patients who achieve healing after definitive treatment.

In this analysis, overall survival (OS) was assessed five years after the last patient was randomized; the median follow-up was 60.1 months (range, 7.1-70.5 months) in the xevinapant arm and 39.2 months (range, 4.8-71.2 months) in the placebo arm. The data shows:

  • Xevinapant more than halved the risk of death over five years of follow-up compared to placebo (adjusted RR, 0.47 [95% CI, 0.27-0.84]; nominal p = 0.0101).

  • Median OS was prolonged with xevinapant (median not reached; 95% CI, 40.3 months – not evaluable) compared to placebo (36.1 months; 95% CI, 21.8-46.7 months ).

  • Treatment with xevinapant almost doubled OS, with a 53% (95% CI, 37-66%) survival probability after five years, compared to 28% (95% CI, 15-42%) with placebo .

As previously reported, the addition of xevinapant to CRT was well tolerated and consistent with the safety profile of CRT alone with a follow-up of approximately two years. Grade 3 or higher adverse events were reported in 41 (85%) of 48 patients in the xevinapant group and 41 (87%) of 47 patients in the placebo group. The most common grade 3 or higher treatment-emergent adverse events in patients who received xevinapant plus CRT and occurring in more than 15% of patients were dysphagia (50%), anemia (35%), mucositis ( 31%) and neutropenia (23%).1 Three-year follow-up analysis showed similar safety.2

“Head and neck cancer is a devastating disease that often has a profound impact on a patient’s ability to eat, communicate and even sleep, yet there have been few advances in treatment over the past 20 years. years,” said Amanda Hollinger, Executive Director, Leader and Neck Cancer Alliance. “We hope these findings will pave the way for a new approach that may improve outcomes.”

Previously reported results from the randomized, double-blind phase II study showed that the addition of xevinapant to standard CRT provided a statistically significant improvement in locoregional control rate at 18 months, the primary endpoint, by versus placebo and CRT in unresected patients. THE SCCHN (54% [95% CI, 39 to 69] against 33% [95% CI, 20 to 48]; odds ratio 2.69 [95% CI, 1.13 to 6.42]; p=0.026). The first results of the study have been published in The Lancet Oncology.1

“The opportunity to develop an oncology drug in a curative setting is a rare privilege, especially for a difficult-to-treat disease such as locally advanced head and neck cancer, where many patients cannot undergo surgery,” said Victoria Zazulina, MD, Head of Development Unit Oncology, Merck KGaA, Darmstadt, Germany. “Based on these Phase II results, we are committed to exploring the potential value of xevinapant in the locally advanced setting through our ongoing Phase III program, as we pioneer the study of the pathway apoptotics as a new treatment modality.

Based on the promising efficacy and safety profile observed in the phase II trial and the urgent need for new treatments, xevinapant is being evaluated in two ongoing phase III clinical trials. The first is the international, randomized, double-blind, placebo-controlled TrilynX study (NCT04459715) to evaluate the efficacy and safety of xevinapant versus placebo when added to definitive CRT in patients with an unresected SCCHN LA. The second is XRay Vision (NCT05386550), a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of xevinapant versus placebo when added to adjuvant postoperative radiotherapy in patients with of resected SCCHN who are at high risk for relapse and are not eligible for cisplatin. TrilynX and XRay Vision are currently recruiting.

In February 2020, the United States Food and Drug Administration granted Breakthrough Therapy Designation to xevinapant (formerly under development with Debiopharm as Debio 1143) for the treatment of patients with previously untreated SCCHN, in combination with current standards of care, based on the results of the phase II trial.

About head and neck cancer

Worldwide, head and neck cancer accounts for more than 870,000 cases and 440,000 deaths per year,3 making it the 8th most common type of cancer. SCCHN is a very debilitating disease that can lead to difficulty breathing, swallowing and speaking as it progresses. Despite treatment with curative intent using standard CRT, approximately 50% of patients with SCCHN develop local recurrence and/or distant metastases,4 which are usually detected within the first two years after the end of the standard treatment, which highlights the need to identify new therapeutic approaches.

About Xevinapant

Xevinapant (formerly known as Debio 1143) is a potent investigational oral small molecule IAP (inhibitor of apoptosis protein) inhibitor for the treatment of SCCHN. In preclinical studies, xevinapant restored susceptibility to apoptosis in cancer cells, enhancing the effects of chemotherapy and radiation therapy. Xevinapant, the most clinically advanced IAP inhibitor, has improved efficacy outcomes in combination with chemoradiotherapy (CRT), including three-year progression-free survival and five-year survival, by versus placebo plus CRT in a phase II study in patients with unresected LA SCCHN. In March 2021, Merck KGaA, Darmstadt, Germany, obtained exclusive rights from Debiopharm to develop and commercialize xevinapant worldwide. Xevinapant is not approved for any use worldwide.

About EMD Serono, Inc.

EMD Serono – the healthcare business of Merck KGaA, Darmstadt, Germany in the United States and Canada – aspires to create, improve and extend the lives of people living with difficult-to-treat conditions such as infertility, multiple sclerosis and cancer. The company imagines the future of healthcare by striving to translate molecule discovery into potentially meaningful outcomes for people with serious unmet medical needs. EMD Serono’s global roots go back over 350 years with Merck KGaA, Darmstadt, Germany. Today, the company has approximately 1,500 employees across the country with commercial, clinical and research operations in Massachusetts. www.emdserono.com.

About Merck KGaA, Darmstadt, Germany

Merck KGaA, Darmstadt, Germany, a leading science and technology company, operates in the fields of life sciences, healthcare and electronics. Approximately 60,000 employees work every day to make a positive difference in the lives of millions of people by creating more enjoyable and sustainable lifestyles. From advancing gene-editing technologies, to discovering unique ways to treat the toughest diseases, to enabling device intelligence, the company is everywhere. In 2021, Merck KGaA, Darmstadt, Germany, achieved sales of €19.7 billion in 66 countries.

The company owns the global rights to the “Merck” name and trademark internationally. The only exceptions are the United States and Canada, where the business areas of Merck KGaA, Darmstadt, Germany, operate as MilliporeSigma in life sciences, EMD Serono in healthcare, and EMD Electronics in electronics. Since its founding in 1668, scientific exploration and responsible entrepreneurship have been at the heart of the company’s technological and scientific advancements. To this day, the founding family remains the majority shareholder of the listed company.

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1 Sun XS Tao Y, Le Tourneau C, et al. Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregional advanced squamous cell carcinoma of the head and neck: a phase 2, multicenter, randomized, double-blind study. Lancet Oncol. 2020 Sep;21(9):1173-1187. doi: 10.1016/S1470-2045(20)30327-2. Published online August 3, 2020.

2 Bourhis J, Sun XS, Le Tourneau C, et al. 3-year follow-up results of randomized, double-blind phase II trial comparing concurrent high-dose cisplatin radiotherapy plus xevinapant (Debio 1143) or placebo in high-risk patients with locally advanced squamous cell carcinoma of head and neck. Oral presentation at: 2020 Virtual ESMO Congress.

3 Sung H, Ferlay J, Siegel RL, et al. World Cancer Statistics 2020: GLOBOCAN estimates of worldwide incidence and mortality for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Published online February 4, 2021.

4 Choong N, Vokes E. Growing role of the medical oncologist in the management of head and neck cancer. CA Cancer J Clin. 2008 Jan-Feb;58(1):32-53. doi: 10.3322/CA.2007.0004. Published online December 20, 2007.

]]> Chariot Ltd forms partnership with Total Eren to develop green hydrogen project in Mauritania https://dcwritersway.org/chariot-ltd-forms-partnership-with-total-eren-to-develop-green-hydrogen-project-in-mauritania/ Tue, 06 Sep 2022 06:32:00 +0000 https://dcwritersway.org/chariot-ltd-forms-partnership-with-total-eren-to-develop-green-hydrogen-project-in-mauritania/

Chariot Ltd (AIM:CHAR, OTC:OIGLF) said it was forming a joint venture with France’s Total Eren to develop the Nour green hydrogen project in Mauritania.

With a 50-50% partnership agreed with the Paris-based renewable energy specialist, the duo will now launch extensive feasibility studies to co-develop the Nour project and said they could also assess other opportunities together. green hydrogen in other African countries.

Chariot said he would “co-lead” project development and licensing, local content and stakeholder engagement and that the partnership would benefit from Total Eren’s dedicated expertise in solar, wind, hybrid and of green hydrogen around the world.

Fabienne Demol, Global Head of Business Development at Total Eren, said: “We are convinced that green hydrogen will be an essential part of tomorrow’s energy mix, and we are delighted to enter into this new partnership on a continent where our shareholder strategy, TotalEnergies, has a strong footprint.

“Our skills complement Chariot’s well and we intend to share our expertise throughout the development of the project.”

Energy supermajor TotalEnergies is a 23% shareholder in Total Eren and has an option to take full control of the renewable energy specialist from this month.

Adonis Pouroulis, CEO of Chariot, said: “We are delighted to have strengthened our partnership with Total Eren, a world leader in renewable energy.

He said having a partner of the caliber of the Paris-based company “is key to developing this valuable asset” and “we look forward to collaborating on other opportunities alongside Total Eren in the future.” .

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Do you live in the Danville mall? City officials and landlords reinvent development as ‘a lifestyle destination’ | Local business news https://dcwritersway.org/do-you-live-in-the-danville-mall-city-officials-and-landlords-reinvent-development-as-a-lifestyle-destination-local-business-news/ Sat, 03 Sep 2022 20:00:00 +0000 https://dcwritersway.org/do-you-live-in-the-danville-mall-city-officials-and-landlords-reinvent-development-as-a-lifestyle-destination-local-business-news/

City officials are working with the owners of the Danville Shopping Center to find new uses for the shopping site.

“We envision the Danville Mall property as a lifestyle destination, where community, retail and residential meet in one place,” said Danville Economic Development Manager Corrie T. Bobe. , at the Danville Register & Bee.

Possible uses for the site include hospitality, residences, outdoor recreation, food and drink, public gathering areas and offices, Bobe said. The mall’s 87,000 square foot footprint and about 17,000 square feet of off-plot development area could be redeveloped, she said.

A spokesman for Hull Property Group, owner of Danville Mall, did not respond to numerous voicemails left this week by the Register & Bee.

City officials have pointed to the mall’s central location as an ideal location for redevelopment.

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“Where it is geographically located, it is perfectly situated to be a lifestyle destination,” said Councilman Lee Vogler. “It’s been a huge commercial site for many years. It’s surrounded by commercial properties. Combining that with residential is a win-win situation.”

City Manager Ken Larking said of the mall property, “It’s centrally located, has great access, it has great views and it’s a beautiful property.”

Malls have been in decline for decades across the country and new uses need to be found for them, Vice Mayor Gary Miller said.

“Malls close every year across the country,” Miller said. “We’re going to have to reinvent what malls do.”






Vehicles fill the Danville Mall parking lot Friday afternoon. City officials have pointed to the mall’s central location as an ideal location for redevelopment.


John R. Crane, register and bee


“Reimagine” was a running theme among officials who spoke to the Register & Bee. Hull Property Group and the city’s economic development office are working together “to determine ways to reinvent this site, providing additional enhanced offerings to our residents,” Bobe said.

“Hull Properties is open to exploring partnership opportunities for further residential and commercial redevelopment of this site,” Bobe said.

Redevelopment of the site would not involve closing the mall, but would add to what already exists, she said.

Miller thinks looking at the mall’s redevelopment options is a great idea.

“We don’t want the mall to go bankrupt,” Miller said.

Danville serves as a commercial hub for surrounding communities in southern Virginia and northern North Carolina, reaching about 625,000 residents, Bobe said. That and other factors make the mall property a perfect choice for redevelopment, she said.

“This property is also located near major city assets including the River District, two of Averett University’s campuses and the $650 million Caesars complex under construction,” Bobe said. “Additionally, this site is located in high traffic areas where between 17,000 and 24,000 cars pass through each day.”

Bobe wouldn’t say if potential developers are watching the mall for possible projects.

“At this time, we cannot comment on prospect activity related to this project,” she said.







Danville Shopping Center

Danville Economic Development Officials are in talks with the Danville Mall owners about a potential redevelopment of the mall property for mixed use including residential, hotel, outdoor recreation, dining, gathering areas public and office spaces.


John R. Crane, register and bee


Any incentives that would be offered for effort on ownership would depend on the size of the project, Bobe said.

“The city will evaluate all potential incentives based on the scope of the final development project,” Bobe said.

A regional housing summit held at the Institute for Advanced Learning and Research highlighted the need for more housing in the city and surrounding region, Miller said. This gives Danville the opportunity to market the mall for a mixed-use development.

“We have to help our mall and we’re happy to do that,” Miller said.

City officials are also considering redeveloping other parts of the city, Bobe said.

The Danville Economic Development Office recently assessed the condition of the city’s major corridors and prioritized areas for redevelopment efforts, Bobe said.

“We are currently focused on redeveloping the Schoolfield District and West Main Street corridor that extends from the North Carolina line and extends to the River District boundaries,” she said.

A Philadelphia company is working on a master plan for the hallway, which is expected to be completed in October, Bobe said. The city will begin to focus its efforts on this area based on the results of the study, she said.

“We will immediately begin planning to implement the recommendations of this study,” Bobe said.

The economic development office is also partnering with the River District Association to assess redevelopment along the North Main hill, she said.

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Global 5G Small Cell Network Industry Expected to Reach $4.7 Billion by 2027 – ResearchAndMarkets.com https://dcwritersway.org/global-5g-small-cell-network-industry-expected-to-reach-4-7-billion-by-2027-researchandmarkets-com/ Wed, 31 Aug 2022 14:09:00 +0000 https://dcwritersway.org/global-5g-small-cell-network-industry-expected-to-reach-4-7-billion-by-2027-researchandmarkets-com/

DUBLIN–(BUSINESS WIRE)–The “Global 5G Small Cell Networks Market (2022-2027)” Report has been added to from ResearchAndMarkets.com offer.

The Global 5G Small Cell Network Market is estimated to be valued at USD 903.1 Million in 2022 and is projected to reach USD 4719.89 Million by 2027, growing at a CAGR of 39.2%.

Market dynamics are forces that are impacting pricing and stakeholder behaviors in the global 5G Small Cell Network market. These forces create price signals that result from changes in the supply and demand curves for a given product or service. The forces of market dynamics can be related to macro-economic and micro-economic factors.

There are dynamic market forces other than price, demand and supply. Human emotions can also drive decisions, influence the market and create price signals. As market dynamics impact supply and demand curves, policymakers aim to determine how best to use various financial tools to stem various strategies aimed at accelerating growth and reducing risk.

Competitive Quadrant

The report includes Competitive Quadrant, a proprietary tool to analyze and assess the position of companies based on their industry position score and market performance score. The tool uses various factors to classify players into four categories. Some of these factors considered for analysis are financial performance over the past 3 years, growth strategies, innovation score, new product launches, investments, market share growth, etc

Ansoff analysis

The report presents a detailed analysis of the Ansoff matrix for the global 5G small cell networks market. Ansoff Matrix, also known as Product/Market Expansion Grid, is a strategic tool used to design business growth strategies. The matrix can be used to assess approaches in four strategies viz. Market development, market penetration, product development and diversification.

The matrix is ​​also used for risk analysis to understand the risk associated with each approach. The analyst analyzes the use of the Ansoff Matrix to provide the best approaches a company can take to improve its market position. Based on the SWOT analysis conducted on the industry and industry players, the analyst has designed appropriate strategies for market growth.

Why buy this report?

  • The report offers a comprehensive assessment of the global 5G small cell network market. The report includes in-depth qualitative analysis, verifiable data from authentic sources, and market size projections. Projections are calculated using proven research methodologies.

  • The report has been compiled through extensive primary and secondary research. The main research is done through interviews, surveys and observations of renowned personnel in the industry.

  • The report includes in-depth market analysis using Porter’s 5 forces model and Ansoff’s matrix. Additionally, the impact of Covid-19 on the market is also presented in the report.

  • The report also includes the regulatory scenario in the industry, which will help you to make an informed decision. The report discusses the major regulatory bodies and major rules and regulations imposed on this industry across various geographies.

  • The report also contains competitive analysis using Positioning Quadrants, the analyst’s proprietary competitive positioning tool.

Market dynamics

Drivers

  • Increase in mobile data traffic

  • Emergence of Citizen Broadband Radio Service Band

  • Growing need to minimize Capex and Opex

Constraints

  • Bad link connectivity

Opportunities

  • Emergence of IoT and M2M communication

  • Emergence of 5G

Challenges

  • Difficulties in deploying small cells in 5G networks

  • Implications of government regulations

Market segmentation

The global 5G small cell network market is segmented on the basis of frequency, 5G application, offers, cell and geography.

  • By frequency, the market is categorized into low frequency and MMwave.

  • By 5G application, the market is categorized into enhanced mobile broadband, massive machine-type communications, and ultra-reliable low-latency communications.

  • By Offers, the market is categorized into Solutions and Services.

  • By cell, the market is categorized into picocells, femtocells, and microcells.

  • By geography, the market is categorized into Americas, Europe, Middle East & Africa, and Asia-Pacific.

Companies cited

  • Ericsson

  • Huawei technology

  • ip access

  • nokia

  • Samsung

  • Airspan Networks

  • Cisco Systems

  • CommScope

  • Comba Telecom

  • told

  • Corning

  • Fujitsu

  • NEC

  • ZTE

  • Baicell Technologies

  • Accelleran

  • Accumulate

  • Home systems

  • Commagility

  • Radisys

  • Altiostar

  • Siradel

  • Qualcomm

  • octasic

  • PC-Tel

  • Microsemi

For more information about this report visit https://www.researchandmarkets.com/r/f3vezs

]]> Are you planning an IPO? Why ESG should be on your checklist https://dcwritersway.org/are-you-planning-an-ipo-why-esg-should-be-on-your-checklist/ Sun, 28 Aug 2022 06:27:50 +0000 https://dcwritersway.org/are-you-planning-an-ipo-why-esg-should-be-on-your-checklist/

By Rajib Debnath, Neha Malhotra, Suhaanvi Sood

The global IPO market has grown stronger in recent years. It is an important step for a company to go public and demonstrate transparency and a larger goal of delivering value to stakeholders. However, with the COVID-19 outbreak causing market volatility, the world has seen a sea change in investment habits. Companies that comply with environmental, social and governance (ESG) standards have been found to perform better and be much more resilient during difficult market times. This led investors to make more responsible decisions and focus on value-oriented investments, which led to a decrease in their risk appetite.

Growing sustainability awareness among investors has resulted in companies adopting and implementing a sustainability strategy in their business models. Embedding ESG policies into business models reflects a company’s long-term prospects, enhanced market reputation, strong competitiveness, financial outperformance of competitors, resulting in transformation of the entire value chain and ecosystem. Moreover, customers also expect companies to contribute to the betterment of the environment and society and prefer brands that match their belief systems.

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Companies considering an IPO should plan to go the route and declare their commitment to ESG from the pre-IPO stage to build credibility and visibility. Thus, voluntary ESG communication/disclosure at the pre-IPO stage is a key factor for a successful start in the capital market. The early stage of ESG insight and measurement benefits IPO valuation and financial performance. This includes its own ESG assessment which improves the level of transparency, attracting the interest of responsible investors, including that of investment funds, as investors perceive ESG-compliant companies as less risky. In addition, greater transparency towards its stakeholders reduces asymmetric information demonstrating that the company is more trustworthy.

The three ESG indicators – environmental, social and governance – quantify the company’s impact on the environment, society, responsibility towards its employees and the company’s vision vis-à-vis its governance. In order to simplify the ESG assessment process for investors, rating institutions have implemented the ESG rating/score concept. The ESG score demonstrates the company’s propensity to integrate ESG, which has become one of the most critical factors for stakeholders, especially at the pre-IPO stage. Companies with good ESG scores have a great competitive advantage that allows them to generate above-average returns. As a result, investors would not demand higher compensation in return and the IPO would not be undervalued, relative to a non-ESG compliant company.

It is observed that ESG rating will soon become mandatory in the same way as credit ratings for companies seeking to raise capital. During the process of building an order book, the underwriter attempts to determine the price at which an IPO will be offered. Additionally, in the IPO process, institutional investors are often involved and are often seen as well-informed investors. Additionally, the underwriter should create incentives for the institutional investor to reveal the price they are willing to pay to facilitate the process of correctly pricing IPO shares.

Venture capitalists and private equity investors have increased their requirements for due diligence and integration of ESG aspects when evaluating potential investments, as ESG integrated funds remain relatively shielded. They want to know at an early stage whether the business has sustainability risks that could negatively impact the value of the business. The world’s largest investors are allocating capital to companies well equipped to benefit from the transition to a green & sustainable economy and are willing to protect their portfolios against downside ESG risks.

Also read: What is the future of stock brokerage technology? BSE Commercial Director Explains

As part of pre-IPO research and ESG assessment, companies should reassess existing models with the aim of understanding their degree of sustainability, assessing their performance in all material ESG aspects, designing a strategy driven by management, linked to the business objective that creates and captures long-term competitive advantage.

Look forward

A company’s ability to create positive environmental and societal impact is rapidly reshaping competitive advantage and companies must simultaneously integrate ESG aspects into every part of the business to take advantage of this transformation.

To tap into as many responsible investors as possible, companies need to broaden their perspective to consider ESG more than just compliance. For companies planning an IPO, ESG is “pre-financial” information rather than “non-financial” information and acts as a listed company before going public.

(Author Rajib Debnath is a partner and co-author Neha Malhotra is Director of Sustainability and Development/CSR Services at Nangia Andersen LLP. The opinions expressed in the article are those of the author and do not reflect the position or the official policy of FinancialExpress.com. )

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Is focused attention always better? New Study Reveals When Not | News | Notre Dame News https://dcwritersway.org/is-focused-attention-always-better-new-study-reveals-when-not-news-notre-dame-news/ Thu, 25 Aug 2022 18:17:53 +0000 https://dcwritersway.org/is-focused-attention-always-better-new-study-reveals-when-not-news-notre-dame-news/
bull’s-eye

In the early 1980s, dental company Colgate decided to pursue the booming convenience food market and launch its own line of frozen meals. Yet, rather than expanding Colgate’s market share, the strategy backfired and resulted in declining revenue and low net income.

According to Michael Mannor, John F. O’Shaughnessy Associate Professor of Family Business at the University of Notre Dame, Colgate’s faux pas is a classic example of a company going against standard expert advice to prioritize sharp focus rather than broad goals.

“For 50 years or more, business consultants and academics have encouraged ambitious CEOs to focus, focus, focus,” said Mannor, a professor at Mendoza College of Business who has spent 15 years researching how structures Organizational challenges can either create challenges for or support CEOs. “But these are people who have been very successful in their organizations – they are captains of industry – who tend to have big business growth plans and who have been selected by boards for their ability stimulate growth.”

WebMike Mannor

Mannor wanted to study the tension between the dominant emphasis on focus and the CEO’s typical tendency toward ambition. He detailed his findings in the article “Keep your eye on the ball or on the pitch? Exploring the Performance Implications of Executive Strategic Attention,” published in the Academy of Management Journal by Mannor and co-author John Eklund of the University of Southern California.

“We wanted to think about how CEOs manage focus versus breadth of opportunity,” Mannor said. “When CEOs focus on a few issues, do they perform better? Or, for CEOs who don’t follow this advice, do their organizations essentially end up chasing squirrels? »

Recognizing that there are no absolutes, Mannor and Eklund hypothesize that leaders should adjust the span of strategic attention based on the quantity and quality of opportunities available and the effectiveness of their business in today’s opportunity landscape. They suspected that when there are fewer low-quality opportunities, executives should expand their network to find potential growth options. Alternatively, if a company is already using its resources efficiently, management should opt for broader strategic attention.

To test this theory, the researchers contacted various leading consulting firms and asked them to characterize and categorize the different types of activities that organizations tend to focus on. They also consulted academic journals and the major trade journals that CEOs often read to determine how these journals characterized strategic opportunities. After gathering all the data, they then asked top professors from different business schools in Europe and North America to evaluate the results. Ultimately, they determined there were 13 categories that represented the range of strategic attention CEOs could focus on. These strategic categories included topics such as joint ventures, customer experience, stakeholder management, risk management, and mergers and acquisitions.

To measure how focused executives are on each category, Mannor and Eklund used software to analyze quarterly earnings call transcripts for language aligned with each of the 13 categories. They pulled the transcripts from a random sample of half of the S&P 500 companies.

“We wanted to have a representative sample of large public companies in part because these are the organizations that are leaders in their industry and have a disproportionate influence on the success and failure of industries as well as the well-being of consumers. “said Mannor.

The analysis confirmed that concentration is indeed the best strategy for a large number of organizations. However, this advice should not be applied universally.

“If a CEO is facing a market where there aren’t a lot of opportunities, focus doesn’t work as well and they need to diversify,” Mannor said. “The same goes for a business that has struggled to convert opportunities into results. So if over the past couple of years they’ve struggled to take their value proposition and make it work effectively, those organizations can benefit from broader strategic attention.

Likewise, if a company is very efficient in the use of its resources, a broader focus can still be very effective. Meanwhile, a company struggling to use its resources efficiently should limit its focus.

“It’s a bit counterintuitive because you’d think if there’s a strong market with lots of opportunities, it would make sense to try and grab them,” Mannor said. “But we see in the data that CEOs end up destroying more value when they try to chase those opportunities. That’s because there’s a tension with cognitive overload. When CEOs and organizations chase too many things, they end up not doing so well at anything. So you spread yourself too thin.

Mannor, who teaches a version of this paper in his graduate courses to expose students to how academic research methods are developed, believes this study can benefit organizations struggling to create value on their market. “Broader attention could be very helpful in moving into new spaces,” he said.

Additionally, investors can use this information to evaluate companies. “Most people have a 401(k) or do some degree of stock investing,” Mannor said. “It gives you a way to look at an organization’s strategies in greater depth and think about the extent to which this company has its attention divided against what its main areas of interest are. It also provides some discipline the average person who buys and sells stocks to not just prioritize innovators who seem to be coming out and looking for a lot of opportunities, because often these companies will underperform those that focus on fundamental value creation.

Originally published on Mendoza News.

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